THE NEXT PARADIGM SHIFT
Delivery: The Bottleneck of Modern Therapeutics
Drug discovery has leapt ahead, but delivery still lags a generation behind. SHIFTBIO is closing this gap with our Programmable NNP (Natural Nanoparticle) Delivery Platform. We solve the fundamental limitations of conventional delivery systems, providing the programmable delivery infrastructure your therapeutic assets need.
CORE CAPABILITIES
The 4 Pillars of Ideal Delivery
01
Targeted Delivery
Organ-specific targeting via NSM scaffold (B-NNP, I-NNP)
02
Versatile Payload Loading
Proteins and RNA, including ASO, siRNA, and mRNA
03
Redosing Capability
Safe and effective for repeat administration
04
Scalable Manufacturability
GMP-ready, >95% purity, 20X yield gain
OUR SOLUTION
Industrializing Cell-derived Nanoparticle
Cell-derived nanoparticles hold strong biological promise but remain difficult to industrialize.
Naive Nanoparticle
Strong biological potential,
but limited industrial readiness
INDUSTRIALIZATION GATE
SHIFTBIO NNP
Natural Nanoparticle
CMC-compliant, predictable, and scalable
We transform biological potential into scalable, pharma-grade therapeutics.
DE-RISKING ENGINE
The NNP Trinity:
Program, Predict, Produce
SHIFTBIO's integrated engine enables
predictable, scalable natural delivery.
NSM Scaffold
PROGRAM
Diversifies payload modalities and targeting design space through programmable engineering
NNP Design AI
PREDICT
Mitigates risk through in silico prediction before wet-lab builds, cutting timelines from months to days
NNP Manufacturing
PRODUCE
Ensures reproducibility and scalability with 200L bioreactor-ready, GMP-grade production
PARTNERSHIP
Partner companies bring their biology.
We provide the delivery infrastructure.
You discover.
We deliver where
it matters most.
THE NEXT PARADIGM SHIFT
Delivery: The Bottleneck of Modern Therapeutics
Drug discovery has leapt ahead, but delivery still lags a generation behind. SHIFTBIO is closing this gap with our Programmable NNP (Natural Nanoparticle) Delivery Platform.
We solve the fundamental limitations of conventional delivery systems, providing the programmable delivery infrastructure your therapeutic assets need.
CORE CAPABILITIES
The 4 Pillars of Ideal Delivery
01
Targeted Delivery
Organ-specific targeting via proprietary NSM scaffold, including BBB-crossing (B-NNP) and inflammation-homing (I-NNP)
02
Versatile Payload Loading
Broad compatibility with both proteins and RNA, including ASO, siRNA, and mRNA
03
Redosing Capability
Safe and effective for repeat administration, overcoming immunogenicity barriers
04
Scalable Manufacturability
GMP-ready production with >95% purity, batch-to-batch consistency, and 20X yield gain
OUR SOLUTION
Industrializing Cell-derived Nanoparticle
Cell-derived nanoparticles hold strong biological promise but remain difficult to industrialize. We transform biological potential into scalable, pharma-grade therapeutics.
Naive Nanoparticle
Strong biological potential,
but limited industrial readiness
INDUSTRIALIZATION
GATE
SHIFTBIO NNP
Natural Nanoparticle
CMC-compliant, predictable,
and scalable
We transform biological potential into scalable, pharma-grade therapeutics.
DE-RISKING ENGINE
The NNP Trinity: Program, Predict, Produce
SHIFTBIO's integrated engine enables predictable, scalable natural delivery.
NSM Scaffold
PROGRAM
Diversifies payload modalities and targeting design space through programmable engineering
NNP Design AI
PREDICT
Mitigates risk through in silico prediction before wet-lab builds, cutting timelines from months to days
NNP Manufacturing
PRODUCE
Ensures reproducibility and scalability with 200L bioreactor-ready, GMP-grade production
PARTNERSHIP
Partner companies bring their biology.
We provide the delivery infrastructure.
You discover.
We deliver where it matters most.
