THE NNP TRINITY
SHIFTBIO's integrated engine transforms cell-derived nanoparticles into a programmable, pharma-grade delivery platform, NNP.
PROGRAM
We uncovered how proteins are selectively enriched in extracellular vesicles and identified a key sorting motif. NSM is our proprietary transmembrane domains that interact with all three major tetraspanins to drive efficient EV sorting.
A universal engineering scaffold that loads hundreds to thousands of therapeutic cargoes per NNP, with plug-and-play targeting for any organ.
High-Density Loading
Engineered to load hundreds to thousands of therapeutic cargoes per NNP
Multi-Cargo Versatility
Unparalleled compatibility with both Proteins and RNA (ASO, siRNA, mRNA)
Plug-and-Play Modularity
Customizing targeting moieties for diverse organ specificity
NSM-Cargo
Variants
Structure
Modeling
Interface
Descriptors
ML Model
Prediction
PREDICT
Predict before you build.
Months, not years.
NSM operates through protein-protein interactions with tetraspanins. This means we can computationally model each Cargo-NSM construct, analyze its tetraspanin interface, and predict engineering success before a single experiment is run.
Standardized biodata across every construct powers a machine learning model that turns structural descriptors into actionable design decisions, dramatically reducing development risk and timeline.
PRODUCE
Successfully industrialized.
At commercial scale.
Cell-derived nanoparticles have long promised biological advantage but resisted industrialization. SHIFTBIO solved this with a scalable manufacturing process that delivers GMP-grade NNPs with 20× yield improvement, >95% purity, and batch-to-batch consistency.
Cell
Bank
200L
Bioreactor
DSP
Purification
NNP
Product
Scaled for Commercial Production
SHIFTBIO has successfully industrialized NNP
200L
Bioreactor Ready
>95%
High Purity
20×
Yield Gain
Nat. Comm.
Published 2025
AI-DRIVEN ITERATIVE DESIGN
A closed-loop cycle where AI predictions are experimentally validated and results refine next-generation designs.
01NNP Design
NSM scaffold + Cargo loading + Targeting moiety
02NNP Design AI™
In silico prediction before wet-lab
03Scalable Manufacturing
Scale-up + High Purity + Consistency
THE NNP TRINITY
SHIFTBIO's integrated engine transforms cell-derived nanoparticles into a programmable, pharma-grade delivery platform, NNP.
PROGRAM
We uncovered how proteins are enriched in extracellular vesicles and identified a key sorting motif. NSM is our proprietary transmembrane domains that interact with all three major tetraspanins to drive efficient EV sorting.
A universal engineering scaffold that loads hundreds to thousands of therapeutic cargoes per NNP, with plug-and-play targeting for any organ.
High-Density Loading
Engineered to load hundreds to thousands of therapeutic cargoes per NNP
Multi-Cargo Versatility
Unparalleled compatibility with both Proteins and RNA (ASO, siRNA, mRNA)
Plug-and-Play Modularity
Customizing targeting moieties for diverse organ specificity
NSM-Cargo
Variants
Structure
Modeling
Interface
Descriptors
ML Model
Prediction
PREDICT
Predict before you build.
Months, not years.
NSM operates through protein-protein interactions with tetraspanins. This means we can computationally model each Cargo-NSM construct, analyze its tetraspanin interface, and predict engineering success before a single experiment is run.
Standardized biodata across every construct powers a machine learning model that turns structural descriptors into actionable design decisions, dramatically reducing development risk and timeline.
PRODUCE
Successfully industrialized.
At commercial scale.
Cell-derived nanoparticles have long promised biological advantage but resisted industrialization. SHIFTBIO solved this with a scalable manufacturing process that delivers GMP-grade NNPs with 20× yield improvement, >95% purity, and batch-to-batch consistency.
Cell
Bank
200L
Bioreactor
DSP
Purification
NNP
Product
Scaled for Commercial Production
SHIFTBIO has successfully industrialized NNP
200L
Bioreactor Ready
>95%
High Purity
20×
Yield Gain
Nat. Comm.
Published 2025
AI-DRIVEN ITERATIVE DESIGN
A closed-loop cycle where AI predictions are experimentally validated and results refine next-generation designs.
01NNP Design
NSM scaffold + Cargo loading + Targeting moiety
02NNP Design AI™
In silico prediction before wet-lab
03Scalable Manufacturing
Scale-up + High Purity + Consistency
