๐ MAKING INNOVATION ACCESSIBLE: Breakthrough Published in Biomaterials!
SHIFTBIO proudly announces groundbreaking research published in Biomaterials (IF 14.0+) - solving one of medicine's greatest challenges: turning unstable therapeutics into powerful, targeted treatments.
๐ฏ The Challenge We Solved: Apelin peptides showed promise for Pulmonary Arterial Hypertension (PAH) but vanished within hours in the bloodstream - until now.
โก Our Innovation: โ
IFITM3-based EV platform - engineered for optimal C-terminal cargo display โ
24-hour plasma stability vs. <1 hour for free peptides โ
Targeted PAH delivery using our novel CARSKNKDC peptide โ
Foundation for NSM 2.0 - next-generation scaffold technology
๐ฅ Real Impact: Reversed vascular remodeling and restored cardiac function in preclinical PAH models - addressing a critical unmet medical need affecting millions worldwide.
This is how we turn the impossible into possible.
Ready to see what's next? ๐
https://www.sciencedirect.com/science/article/pii/S0142961225003576
๐ MAKING INNOVATION ACCESSIBLE: Breakthrough Published in Biomaterials!
SHIFTBIO proudly announces groundbreaking research published in Biomaterials (IF 14.0+) - solving one of medicine's greatest challenges: turning unstable therapeutics into powerful, targeted treatments.
๐ฏ The Challenge We Solved: Apelin peptides showed promise for Pulmonary Arterial Hypertension (PAH) but vanished within hours in the bloodstream - until now.
โก Our Innovation: โ IFITM3-based EV platform - engineered for optimal C-terminal cargo display โ 24-hour plasma stability vs. <1 hour for free peptides โ Targeted PAH delivery using our novel CARSKNKDC peptide โ Foundation for NSM 2.0 - next-generation scaffold technology
๐ฅ Real Impact: Reversed vascular remodeling and restored cardiac function in preclinical PAH models - addressing a critical unmet medical need affecting millions worldwide.
This is how we turn the impossible into possible.
Ready to see what's next? ๐
https://www.sciencedirect.com/science/article/pii/S0142961225003576