We are delighted to share the preprint of our second program, HIF1α-NNP.
This manuscript showcases in vivo macrophage reprogramming by NNP (natural nanoparticle) mediated delivery of transcription factor HIF1α for enhanced trained immunity. Delivering HIF1a to macrophages during severe inflammatory conditions promoted the differentiation of Nr1h3-dependent pro-efferocytic and Cebpb-dependent pro-survival MoMFs. Pro-efferocytic MoMFs eliminate damaged cells, and pro-survival MoMFs withstand inflammatory conditions and trigger innate memory responses. This study highlights that NNP-mediated transcription factor delivery for in vivo macrophage reprogramming could be a promising therapeutic option for managing inflammatory diseases.
The outstanding members of KIST led this work in collaboration with SHIFTBIO.
Check out the full preprint here:
https://www.biorxiv.org/content/10.1101/2024.08.29.608900v1
We are delighted to share the preprint of our second program, HIF1α-NNP.
This manuscript showcases in vivo macrophage reprogramming by NNP (natural nanoparticle) mediated delivery of transcription factor HIF1α for enhanced trained immunity. Delivering HIF1a to macrophages during severe inflammatory conditions promoted the differentiation of Nr1h3-dependent pro-efferocytic and Cebpb-dependent pro-survival MoMFs. Pro-efferocytic MoMFs eliminate damaged cells, and pro-survival MoMFs withstand inflammatory conditions and trigger innate memory responses. This study highlights that NNP-mediated transcription factor delivery for in vivo macrophage reprogramming could be a promising therapeutic option for managing inflammatory diseases.
The outstanding members of KIST led this work in collaboration with SHIFTBIO.
Check out the full preprint here:
https://www.biorxiv.org/content/10.1101/2024.08.29.608900v1