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Innovative NNP Design Approach for Revolutionary Targeted Delivery


SHIFTBIO developed platforms for designing Natural Nanoparticles (NNPs), safe drug delivery vehicles that can reach desired locations in the body from cellular origins 

NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

Innovative NNP Design Approach for Revolutionary Targeted Delivery


SHIFTBIO developed platform technologies for NSM designed Natural Nanoparticles (NNPs), 

safe drug delivery vehicles that can reach desired locations in the body from cellular origins


NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

Key Advantages

High design success rate

Multiplex cargo loading

Universal cell applications

Key Advantages

High design 

success rate

Multiplex 

cargo loading

Universal 

cell applications


NNP Design AI™ Platform 

NNP Design AI™ predicts
NSM-driven NNP generation, 

enabling low-risk development

of breakthrough delivery vehicles

01


NSM structure modeling

02


Predicting NSM-based NNP generation success rate 

through PPI analysis



03


Refining NNP through 

MD simulations



NNP Design AI™ Platform 


NNP Design AI™ predicts NNP generation, 

enabling low-risk development of breakthrough delivery vehicles

01 


NSM structure modeling


02


Predicting NSM-based NNP generation success rate through PPI analysis




03


Refining NNP through 

MD simulations



Traditional Drug Design Strategy

NNP Design AI™ Platform
4–5 years or more
Period
A few months
High
Cost
Low
Complex experiments, repetitive validation


Process
Simple data analysis and prediction

High
Failure Risk
Low (Early risk prediction)

NNP Design AI™ dramatically reduces the time and cost of NNP drug development 

NNP Designing for Targeted Delivery


We create NNPs that effectively deliver payloads to target organs/cells through our proprietary scaffold

Traditional Drug Delivery Development Strategy


Period
4–5 years or more
Cost
High
Process
Complex experiments,
repetitive validation

NNP Design AI™ Platform


Period
A few months
Cost
Low
Process
Simple data analysis
and prediction

Failure Risk
Low
(Early risk prediction)

NNP Design AI™ dramatically 

reduces the time and cost 

of NNP drug development

NNP Designing
for Targeted Delivery


We create NNPs that effectively deliver payloads to target organs/cells 

through our proprietary scaffold