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Innovative Approach 
for NNP Engineering


SHIFTBIO developed engineering scaffolds
(NNP Sorting Motif, NSM) that are effectively
transported to NNPs through tetraspanin
interactions and load cargos linked
to NSM onto/within NNPs 

NNP Sorting Motif (NSM)

Endogenous engineering mechanism

Innovative Approach for NNP Engineering


SHIFTBIO developed engineering scaffolds (NNP Sorting Motif, NSM) that are effectively transported to NNPs
through tetraspanin interactions and load cargos linked to NSM onto/within NNPs 

NNP Sorting Motif (NSM)

Endogenous engineering mechanism

Key Advantages

High engineering efficiency

Multiplex cargo loading

Universal cell applications

Key Advantages

High engineering
efficiency

Multiplex 

cargo loading

Universal 

cell applications


NNP Design AI™ Platform 

NNP Design AI™ deciphers
NNP engineering mechanisms of NSM,
enabling us to optimize
NSM-cargo sequences

01


3D structure Prediction

02


Identify PPI patterns,
optimize docking poses,
and predict excipient
interactions using
AI-driven analysis



03


Refine structures through
molecular dynamics simulations



01 


3D structure
Prediction


02


Identify PPI patterns, optimize docking poses, and predict excipient interactions using 

AI-driven analysis




03


Refine structures through molecular dynamics simulations



Since NSM functions through protein-protein interactions,
in silico molecular modeling systems enable the precise prediction of NNP engineering 

Traditional Drug Design Strategy

NNP Design AI™ Platform
4–5 years or more
Period
A few months
High
Cost
Low
Complex experiments, repetitive validation


Process
Simple data analysis and prediction

High
Failure Risk
Low (Early risk prediction)

AI-driven Natural Drug Delivery Platform
dramatically reduces the time and cost of NNP drug development 

NNP Engineering for In Vivo Delivery


We create engineered NNPs that effectively deliver payloads to target organs/cells through our proprietary scaffold

Since NSM functions through
protein-protein interactions,
in silico molecular modeling systems
enable the precise prediction of
NNP engineering 

Traditional
Drug Design Strategy


Period
4–5 years or more
Cost
High
Process
Complex experiments,
repetitive validation

NNP Design AI™ Platform


Period
A few months
Cost
Low
Process
Simple data analysis
and prediction

Failure Risk
Low
(Early risk prediction)

AI-driven Natural Drug Delivery Platform
dramatically reduces the time
and cost of NNP drug development 

NNP Engineering 
for In Vivo Delivery


We create engineered NNPs
that effectively deliver payloads to target
organs/cells through our proprietary scaffold