SHIFTBIO developed engineering scaffolds
(NNP Sorting Motif, NSM) that are effectively
transported to NNPs through tetraspanin
interactions and load cargos linked
to NSM onto/within NNPs
NNP Sorting Motif (NSM)
Endogenous engineering mechanism
SHIFTBIO developed engineering scaffolds (NNP Sorting Motif, NSM) that are effectively transported to NNPs
through tetraspanin interactions and load cargos linked to NSM onto/within NNPs
NNP Sorting Motif (NSM)
Endogenous engineering mechanism
High engineering efficiency | Multiplex cargo loading | Universal cell applications |
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Key Advantages
High engineering | Multiplex cargo loading | Universal cell applications |
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NNP Design AI™ deciphers
NNP engineering mechanisms of NSM,
enabling us to optimize
NSM-cargo sequences
01
3D structure Prediction
02
Identify PPI patterns,
optimize docking poses,
and predict excipient
interactions using
AI-driven analysis
03
Refine structures through
molecular dynamics simulations
NNP Design AI™ deciphers NNP engineering mechanisms of NSM,
enabling us to optimize NSM-cargo sequences
01
3D structure
Prediction
02
Identify PPI patterns, optimize docking poses, and predict excipient interactions using
AI-driven analysis
03
Refine structures through molecular dynamics simulations
Since NSM functions through protein-protein interactions,
in silico molecular modeling systems enable the precise prediction of NNP engineering
Traditional Drug Design Strategy | NNP Design AI™ Platform |
4–5 years or more | Period | A few months |
High | Cost | Low |
Complex experiments, repetitive validation | Process | Simple data analysis and prediction |
High | Failure Risk | Low (Early risk prediction) |
AI-driven Natural Drug Delivery Platform
dramatically reduces the time and cost of NNP drug development
We create engineered NNPs that effectively deliver payloads to target organs/cells through our proprietary scaffold
Since NSM functions through
protein-protein interactions,
in silico molecular modeling systems
enable the precise prediction of
NNP engineering
Period | 4–5 years or more |
Cost | High |
Process | Complex experiments, repetitive validation |
NNP Design AI™ Platform
Period | A few months |
Cost | Low |
Process | Simple data analysis and prediction |
Failure Risk | Low (Early risk prediction) |
AI-driven Natural Drug Delivery Platform
dramatically reduces the time
and cost of NNP drug development
We create engineered NNPs
that effectively deliver payloads to target
organs/cells through our proprietary scaffold