Partnership

Partnership Model

You define the therapeutic biology.
SHIFTBIO turns it into tissue-directed delivery.

YOU BRING

Therapeutic payload

ASO · siRNA
Protein · mRNA

Disease biology

Target · mechanism
indication expertise

Partners bring therapeutic payloads and disease biology. SHIFTBIO provides the delivery engine to reach the right tissue and cell type.

SHIFTBIO Engine

NNP Platform

Programmable · Scalable · GMP-ready

I-NNP

CD47-High Tissue Delivery

Inflammation · fibrosis · autoimmunity

B-NNP

BBB-Guided CNS Delivery

BBB crossing · deep parenchyma

Where It Matters Most

Payloads are delivered to the right tissue and cell type with reproducible biodistribution.

Inflammatory, fibrotic, and autoimmune tissues

IBD · IPF · MASH · AKI

CNS deep parenchyma

Neurodegeneration

Internal Pipeline

I-NNP Lead Programs

SBI-101 / SBI-102

CD47-guided delivery + SIRPα-mediated blockade

01 Delivery

Selective accumulation

Surface SIRPα guides I-NNP to CD47-high inflammatory and fibrotic tissues.

02 Therapeutics

Built-in CD47 blockade

I-NNP blocks the CD47-SIRPα “don’t eat me” signal while delivering therapeutic payloads to diseased tissue.

Orphan Drug Designated

Pre-IND Meeting Completed

Clinical Entry Planned

SBI-101 and SBI-102 serve as lead anchors for the I-NNP platform and de-risk future partnered payload programs.

Let's Collaborate

Ready to deliver where it matters most?

Bring your therapeutic payload and disease biology. We’ll deliver it to the right tissue and the right cell type.

Contact Us →

contact@shiftbio.net