SHIFTBIO Program,
In Vivo Cell Therapy Platform 

Leveraging our NNP Design AI platform,
we optimize NSM-Cargo sequences
engineered into NNPs,
enabling transformative

in vivo cell reprogramming therapeutics. 

SIRP-NNP-MSC
Program
MoATargeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos
Indication(s)Inflammatory / Fibrotic Diseases
Outer CargoSIRPα
Inner CargoRegenerative factor
SIRP-NNP-ASO
Program
MoATargeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly
Indication(s)Inflammatory Bowel Disease
Outer CargoSIRPα
Inner CargoNLRP3 ASO
SIRP-NNP-siRNA
Program
MoATargeting tumor cells and efficiently delivering siRNA intracellularly
Indication(s)Cold Tumor
Outer CargoSIRPα
Inner CargosiRNA (TBD)
CBD-NNP-HIF1α
Program
MoAEnabling sustained release and enhancing resolutive immunity through HIF-1α delivery
Indication(s)Diabetic Ulcer
Outer CargoCollagen binding domain
Inner CargoHIF1α Transcription Factor
Ape-C-NNP-MSC
Program
MoATargeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos
Indication(s)Pulmonary Arterial Hypertension
Outer CargoApelin + CAR peptide
Inner CargoRegenerative factor
tBBB-NNP-Oligo
Program
MoABBB penetration for beta-amyloid clearance
Indication(s)Alzheimer's Disease
Outer CargoTFR1 binding moiety
Inner CargoOligonucleotide (TBD)
SHIFTBIO Program, In Vivo Cell Therapy Platform 

Leveraging our NNP Design AI platform, we optimize NSM-Cargo sequences engineered into NNPs,
enabling transformative in vivo cell reprogramming therapeutics. 


SIRP-NNP-MSC
SIRP-NNP-ASO
SIRP-NNP-siRNA
CBD-NNP-HIF1α
Ape-C-NNP-MSC
tBBB-NNP-Oligo
Program
MoA
Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos
Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly
Targeting tumor cells and efficiently delivering siRNA intracellularly
Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery
Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos
BBB penetration for beta-amyloid clearance
Indication(s)
Inflammatory / Fibrotic Diseases
Inflammatory Bowel Disease
Cold Tumor
Diabetic Ulcer
Pulmonary Arterial Hypertension
Alzheimer's Disease
Outer Cargo
SIRPα
SIRPα
SIRPα
Collagen binding domain
Apelin + CAR peptide
TFR1 binding moiety
Inner Cargo
Regenerative factor
NLRP3 ASO
siRNA (TBD)
HIF1α Transcription Factor
Regenerative factor
Oligonucleotide (TBD)