| SIRP-NNP-MSC | |
| Program |  |
|---|---|
| MoA | Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos |
| Indication(s) | Inflammatory / Fibrotic Diseases |
| Outer Cargo | SIRPα |
| Inner Cargo | Regenerative factor |
| SIRP-NNP-ASO | |
| Program |  |
|---|---|
| MoA | Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly |
| Indication(s) | Inflammatory Bowel Disease |
| Outer Cargo | SIRPα |
| Inner Cargo | NLRP3 ASO |
| SIRP-NNP-siRNA | |
| Program |  |
|---|---|
| MoA | Targeting tumor cells and efficiently delivering siRNA intracellularly |
| Indication(s) | Cold Tumor |
| Outer Cargo | SIRPα |
| Inner Cargo | siRNA (TBD) |
| CBD-NNP-HIF1α | |
| Program |  |
|---|---|
| MoA | Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery |
| Indication(s) | Diabetic Ulcer |
| Outer Cargo | Collagen binding domain |
| Inner Cargo | HIF1α Transcription Factor |
| Ape-C-NNP-MSC | |
| Program |  |
|---|---|
| MoA | Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos |
| Indication(s) | Pulmonary Arterial Hypertension |
| Outer Cargo | Apelin + CAR peptide |
| Inner Cargo | Regenerative factor |
| tBBB-NNP-Oligo | |
| Program |  |
|---|---|
| MoA | BBB penetration for beta-amyloid clearance |
| Indication(s) | Alzheimer's Disease |
| Outer Cargo | TFR1 binding moiety |
| Inner Cargo | Oligonucleotide (TBD) |
SIRP-NNP-MSC | SIRP-NNP-ASO | SIRP-NNP-siRNA | CBD-NNP-HIF1α | Ape-C-NNP-MSC | tBBB-NNP-Oligo | |
|---|---|---|---|---|---|---|
Program | | | | | | |
MoA | Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos | Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly | Targeting tumor cells and efficiently delivering siRNA intracellularly | Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery | Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos | BBB penetration for beta-amyloid clearance |
Indication(s) | Inflammatory / Fibrotic Diseases | Inflammatory Bowel Disease | Cold Tumor | Diabetic Ulcer | Pulmonary Arterial Hypertension | Alzheimer's Disease |
Outer Cargo | SIRPα | SIRPα | SIRPα | Collagen binding domain | Apelin + CAR peptide | TFR1 binding moiety |
Inner Cargo | Regenerative factor | NLRP3 ASO | siRNA (TBD) | HIF1α Transcription Factor | Regenerative factor | Oligonucleotide (TBD) |
