Leveraging our NNP Design AI platform,
we optimize NSM-Cargo sequences
engineered into NNPs,
enabling transformative
in vivo cell reprogramming therapeutics.
SIRP-NNP-MSC | |
Program | ![]() |
---|---|
MoA | Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos |
Indication(s) | Inflammatory / Fibrotic Diseases |
Outer Cargo | SIRPα |
Inner Cargo | Regenerative factor |
SIRP-NNP-ASO | |
Program | ![]() |
---|---|
MoA | Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly |
Indication(s) | Inflammatory Bowel Disease |
Outer Cargo | SIRPα |
Inner Cargo | NLRP3 ASO |
SIRP-NNP-siRNA | |
Program | ![]() |
---|---|
MoA | Targeting tumor cells and efficiently delivering siRNA intracellularly |
Indication(s) | Cold Tumor |
Outer Cargo | SIRPα |
Inner Cargo | siRNA (TBD) |
CBD-NNP-HIF1α | |
Program | ![]() |
---|---|
MoA | Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery |
Indication(s) | Diabetic Ulcer |
Outer Cargo | Collagen binding domain |
Inner Cargo | HIF1α Transcription Factor |
Ape-C-NNP-MSC | |
Program | ![]() |
---|---|
MoA | Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos |
Indication(s) | Pulmonary Arterial Hypertension |
Outer Cargo | Apelin + CAR peptide |
Inner Cargo | Regenerative factor |
tBBB-NNP-Oligo | |
Program | ![]() |
---|---|
MoA | BBB penetration for beta-amyloid clearance |
Indication(s) | Alzheimer's Disease |
Outer Cargo | TFR1 binding moiety |
Inner Cargo | Oligonucleotide (TBD) |
Leveraging our NNP Design AI platform, we optimize NSM-Cargo sequences engineered into NNPs,
enabling transformative in vivo cell reprogramming therapeutics.
SIRP-NNP-MSC | SIRP-NNP-ASO | SIRP-NNP-siRNA | CBD-NNP-HIF1α | Ape-C-NNP-MSC | tBBB-NNP-Oligo | |
---|---|---|---|---|---|---|
Program | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() |
MoA | Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos | Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly | Targeting tumor cells and efficiently delivering siRNA intracellularly | Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery | Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos | BBB penetration for beta-amyloid clearance |
Indication(s) | Inflammatory / Fibrotic Diseases | Inflammatory Bowel Disease | Cold Tumor | Diabetic Ulcer | Pulmonary Arterial Hypertension | Alzheimer's Disease |
Outer Cargo | SIRPα | SIRPα | SIRPα | Collagen binding domain | Apelin + CAR peptide | TFR1 binding moiety |
Inner Cargo | Regenerative factor | NLRP3 ASO | siRNA (TBD) | HIF1α Transcription Factor | Regenerative factor | Oligonucleotide (TBD) |