SHIFTBIO’s natural drug delivery platform-based programs
aim to treat rare and refractory diseases with high unmet medical needs
SBI-102 [SIRP-NNP] Membrane Protein | ||
Discovery | IND-enabling | Clinical |
Acute Liver Failure (ALF) | ||
Rare | ||
Necroptosis Resolution | ||
Orphan Drug Designated | ||
Severe Alcoholic Hepatitis | ||
Rare | ||
Necroptosis Resolution | ||
Idiopathic Pulmonary Fibrosis | ||
Rare | ||
Phagocytosis of Pathological Fibroblasts | ||
Metabolic Dysfunction-Associated | ||
Refractory | ||
Necroptosis Resolution /Phagocytosis of Pathological Fibroblasts | ||
Inflammatory Bowel Disease | ||
Refractory | ||
Necroptosis Resolution | ||
Undisclosed | ||
Refractory | ||
Phagocytosis of Tumor Cells | ||
SBI-201 [HIF1α-NNP] Transcription Factor | ||
Discovery | IND-enabling | Clinical |
Peripheral Arterial Disease (PAD) | ||
Undisclosed | ||
| Resolutive Immunity Activation | ||
SBI-301 siRNA | ||
Discovery | IND-enabling | Clinical |
Undisclosed | ||
Undisclosed | ||
| Undisclosed | ||
SBI-401 mRNA | ||
Discovery | IND-enabling | Clinical |
Undisclosed | ||
Undisclosed | ||
| Undisclosed | ||
aim to treat rare and refractory diseases with high unmet medical needs
Program | Modality | Indication | Type | Mode of Action | Discovery | IND-enabling | Clinical |
SBI-102 [SIRP-NNP] | Membrane Protein | Acute Liver Failure | Rare | Necroptosis Resolution | Orphan Drug Designated | ||
Severe Alcoholic Hepatitis | Rare | Necroptosis Resolution | |||||
Idiopathic Pulmonary Fibrosis | Rare | Phagocytosis of Pathological Fibroblasts | |||||
Metabolic Dysfunction-Associated Steatohepatitis | Refractory | Necroptosis Resolution /Phagocytosis of Pathological Fibroblasts | |||||
Inflammatory Bowel Disease | Refractory | Necroptosis Resolution | |||||
Undisclosed | Refractory | Phagocytosis of Tumor Cells | |||||
SBI-201 [HIF1α-NNP] | Transcription Factor | Peripheral Arterial | Undisclosed | Resolutive Immunity Activation | |||
SBI-301 | siRNA | Undisclosed | Undisclosed | Undisclosed | |||
SBI-302 | mRNA | Undisclosed | Undisclosed | Undisclosed | |||
