Notifications
Back
SHIFTBIO NNP Design AI™

Innovative NNP Design for Revolutionary Targeted Delivery


Our proprietary NSM scaffold harnesses cellular biogenesis to generate precision-targeted natural nanoparticles (NNPs) that deliver diverse payloads directly to their intended sites

NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

SHIFTBIO NNP Design AI™
Innovative NNP Design for Revolutionary Targeted Delivery


Our proprietary NSM scaffold harnesses cellular biogenesis to generate 

precision-targeted natural nanoparticles (NNPs) that deliver diverse payloads directly to their intended sites


NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

Key Advantages

High design success rate

Multiplex cargo loading

Universal cell applications

Key Advantages

High design 

success rate

Multiplex 

cargo loading

Universal cell

applications


NNP Design AI™ Platform 

NSM operates through protein-protein interactions (PPIs), enabling precise NNP design prediction using in silico molecular modeling

01


NSM structure modeling

02


Predicting NSM-based 

NNP generation success rate 

through PPI analysis



03


Refining NNP through 

MD simulations



NNP Design AI™ Platform 


NSM operates through protein-protein interactions (PPIs), 

enabling precise NNP design prediction using in silico molecular modeling

01 


NSM structure modeling


02


Predicting NSM-based NNP generation success rate through PPI analysis




03


Refining NNP through 

MD simulations



Traditional Drug Design Strategy

NNP Design AI™ Platform
4–5 years or more
Period
A few months
High
Cost
Low
Complex experiments, repetitive validation


Process
Simple data analysis and prediction

High
Failure Risk
Low (Risk mitigation)

NNP Design AI™ predicts NSM-driven NNP generation, 

enabling low-risk development of breakthrough delivery vehicles

NNP Designing for Targeted Delivery


Our platform enables us to develop NNPs that effectively deliver payloads to target organs/cells

Traditional Drug Delivery Development Strategy


Period
4–5 years or more
Cost
High
Process
Complex experiments,
repetitive validation

NNP Design AI™ Platform


Period
A few months
Cost
Low
Process
Simple data analysis
and prediction

Failure Risk
Low (risk mitigation)

NNP Design AI™ predicts
NSM-driven NNP generation,

enabling low-risk development

of breakthrough delivery vehicles

NNP Designing
for In Vivo Delivery


Our platform enables us to develop NNPs that effectively deliver payloads to target organs/cells