SIRP-NNP (SBI-102)


Engineered stem cell-derived SIRP-NNP pioneers the concept of regenerative immunotherapy,
 reprogramming macrophages toward inflammation-resolving and regenerative phenotypes

SIRP-NNP (SBI-102)


Engineered stem cell-derived SIRP-NNP pioneers the concept of regenerative 

immunotherapy, reprogramming

macrophages toward inflammation-

resolving and regenerative phenotypes 

SIRP-NNP


Targeted Delivery
to Inflamed Tissue





Targeting CD47, overexpressed on inflamed tissues, enables targeted delivery and macrophage-mediated clearance


Delivering MSC cargo


Delivering MSC-derived SIRP-NNP’s
regenerative cargo
 to macrophages 


In vivo macrophage reprogramming



CD47 Overexpression
in Inflamed Tissues


In vivo Macrophage
Reprogramming


Recovery