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SHIFTBIO NNP Design AI™

Innovative NNP Design for Revolutionary Targeted Delivery


Our proprietary NSM scaffold harnesses cellular biogenesis to generate precision-targeted natural nanoparticles (NNPs) that deliver diverse payloads directly to their intended sites

NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

SHIFTBIO NNP Design AI™
Innovative NNP Design for Revolutionary Targeted Delivery


SHIFTBIO’s de-risking engine enables predictable, scalable natural delivery.


Key Advantages

High design 

success rate

Multiplex 

cargo loading

Universal cell

applications


NNP Design AI™ Platform 

NSM operates through protein-protein interactions (PPIs), enabling precise NNP design prediction using in silico molecular modeling

01


NSM structure modeling

02


Predicting NSM-based 

NNP generation success rate 

through PPI analysis



03


Refining NNP through 

MD simulations



NNP Design AI™ Platform 


NSM operates through protein-protein interactions (PPIs), 

enabling precise NNP design prediction using in silico molecular modeling

01 


NSM structure modeling


02


Predicting NSM-based NNP generation success rate through PPI analysis




03


Refining NNP through 

MD simulations



Traditional Drug Design Strategy

NNP Design AI™ Platform
4–5 years or more
Period
A few months
High
Cost
Low
Complex experiments, repetitive validation


Process
Simple data analysis and prediction

High
Failure Risk
Low (Risk mitigation)

NNP Design AI™ predicts NSM-driven NNP generation, 

enabling low-risk development of breakthrough delivery vehicles

NNP Designing for Targeted Delivery


Our platform enables us to develop NNPs that effectively deliver payloads to target organs/cells

Traditional Drug Delivery Development Strategy


Period
4–5 years or more
Cost
High
Process
Complex experiments,
repetitive validation

NNP Design AI™ Platform


Period
A few months
Cost
Low
Process
Simple data analysis
and prediction

Failure Risk
Low (risk mitigation)

NNP Design AI™ predicts
NSM-driven NNP generation,

enabling low-risk development

of breakthrough delivery vehicles

NNP Designing
for In Vivo Delivery


Our platform enables us to develop NNPs that effectively deliver payloads to target organs/cells