Natural Drug Delivery
Platform Technology


We have developed a drug engineering scaffold (NNP Sorting Motif, NSM) that is effectively transported to NNPs and loads cargos linked to NSM into NNPs



Strength of Natural Drug
Delivery Platform


The NSM technology is distinguished from competitive technologies by its high cargo loading efficiency
the ability to load multiple types of cargo simultaneously, and broad applicability across different cell types 




Application of Natural Drug Delivery Platform


The NSM platform technology is designed to efficiently deliver a wide array of therapeutic cargos, including membrane proteins, transcription factors, and various nucleic acids such as mRNA, ASO, and siRNA



Cargo Flexibility

 




Delivery Strategy


Enhanced Targetability 
and Selectivity

Enhanced Intracellular
Delivery


Innovative Approach for NNP Engineering


SHIFTBIO developed engineering scaffolds (NNP Sorting Motif, NSM) that are effectively transported to NNPs
through tetraspanin interactions and load cargos linked to NSM onto/within NNPs 

NNP Sorting Motif (NSM)

Endogenous engineering mechanism

01  |  High engineering efficiency

02  |  Multiplex cargo loading

03  |  Universal cell applications

NNP Design AI™ Platform 


NNP Design AI™ deciphers NNP engineering mechanisms of NSM,
enabling us to optimize NSM-cargo sequences

01 


3D structure
Prediction

02


Identify PPI patterns, optimize docking poses, and predict excipient interactions using AI-driven analysis




03


Refine structures through molecular dynamics simulations



Strength of Natural Drug Delivery Platform


The NSM technology is distinguished from competitive technologies by its high cargo loading efficiency
the ability to load multiple types of cargo simultaneously, and broad applicability across different cell types 




Application of Natural Drug Delivery Platform


The NSM platform technology is designed to efficiently deliver a wide array of therapeutic cargos, including membrane proteins, transcription factors, and various nucleic acids such as mRNA, ASO, and siRNA



Cargo Flexibility

 





Delivery Strategy



Enhanced Targetability and Selectivity

Enhanced Intracellular Delivery