Overview 백업 20240503

SBI-102 [SIRP-EV] Membrane Protein
Discovery	IND-enabling	Clinical
Severe Alcoholic Hepatitis /Acute Liver Failure (ALF) ODD
Rare
Efferocytosis of Inflammatory Dying Cells

Acute on Chronic Liver Failure (ACLF)
Rare
Efferocytosis of Inflammatory Dying Cells /Phagocytosis of Pathological Fibroblasts

Idiopathic Pulmonary Fibrosis (IPF)
Rare
Phagocytosis of Pathological Fibroblasts

Pulmonary Arterial Hypertension (PAH)
Rare
Phagocytosis of Pathological Fibroblasts

Nonalcoholic Steatohepatitis (NASH)
Refractory
Phagocytosis of Pathological Fibroblasts

MSS Colorectal Cancer
Refractory
Phagocytosis of Cancer Cells

	SIRP-NNP-MSC	SIRP-NNP-ASO	SIRP-NNP-siRNA	CBD-NNP-HIF1α	Ape-C-NNP-MSC	tBBB-NNP-Oligo
Program
MoA	Targeting CD47-overexpressing cells and reprogramming macrophages with MSC cargos	Targeting inflammatory lesions and efficiently delivering NLRP3 ASO intracellularly	Targeting tumor cells and efficiently delivering siRNA intracellularly	Enabling sustained release and enhancing resolutive immunity through HIF-1α delivery	Targeting pathological lesions and protecting cardiovascular function with apelin and MSC cargos	BBB penetration for beta-amyloid clearance
Indication(s)	Inflammatory / Fibrotic Diseases	Inflammatory Bowel Disease	Cold Tumor	Diabetic Ulcer	Pulmonary Arterial Hypertension	Alzheimer's Disease
Outer Cargo	SIRPα	SIRPα	SIRPα	Collagen binding domain	Apelin + CAR peptide	TFR1 binding moiety
Inner Cargo	Regenerative factor	NLRP3 ASO	siRNA (TBD)	HIF1α Transcription Factor	Regenerative factor	Oligonucleotide (TBD)

Program	Modality	Indication	Type	Mode of Action	Discovery	IND-enabling	Clinical
SBI-102 [SIRP-EV]	Membrane Protein	Severe Alcoholic Hepatitis /Acute Liver Failure (ALF) ODD	Rare	Efferocytosis of Inflammatory Dying Cells
		Acute on Chronic Liver Failure (ACLF)	Rare	Efferocytosis of Inflammatory Dying Cells /Phagocytosis of Pathological Fibroblasts
		Idiopathic Pulmonary Fibrosis (IPF)	Rare	Phagocytosis of Pathological Fibroblasts
		Pulmonary Arterial Hypertension (PAH)	Rare	Phagocytosis of Pathological Fibroblasts
		Nonalcoholic Steatohepatitis (NASH)	Refractory	Phagocytosis of Pathological Fibroblasts
		MSS Colorectal Cancer	Refractory	Phagocytosis of Cancer Cells
SBI-201 [HIF1α-EV]	Transcription Factor	Peripheral Arterial Disease (PAD)	Undisclosed	Resolutive Immunity Activation
SBI-301	ASO	Undisclosed	Undisclosed	Undisclosed
SBI-302	siRNA	Undisclosed	Undisclosed	Undisclosed