SBI-102 [SIRP-NV] Membrane Protein | ||
Discovery | IND-enabling | Clinical |
Acute Liver Failure (ALF) /Severe Alcoholic Hepatitis | ||
Rare | ||
Efferocytosis of Inflammatory Dying Cells | ||
Acute on Chronic Liver Failure (ACLF) | ||
Rare | ||
Efferocytosis of Inflammatory Dying Cells /Phagocytosis of Pathological Fibroblast | ||
Pulmonary Arterial Hypertension (PAH) | ||
Rare | ||
Phagocytosis of Pathological Fibroblast | ||
Idiopathic Pulmonary Fibrosis (IPF) | ||
Rare | ||
Phagocytosis of Pathological Fibroblast | ||
Liver Fibrosis | ||
Refractory | ||
Phagocytosis of Pathological Fibroblast | ||
MSS Colorectal Cancer | ||
Refractory | ||
Phagocytosis of Cancer Cell | ||
SBI-201 [HIF1α-NV] Transcription Factor | ||
Discovery | IND-enabling | Clinical |
Undisclosed | ||
Resolutive Immunity Activation | ||
SBI-301 mRNA | ||
Discovery | IND-enabling | Clinical |
Undisclosed | ||
Undisclosed | ||
SBI-302 siRNA | ||
Discovery | IND-enabling | Clinical |
Undisclosed | ||
Undisclosed | ||
Program | Modality | Indication | Type | Mode of Action | Discovery | IND-enabling | Clinical |
SBI-102 [SIRP-NV] | Membrane Protein | Acute Liver Failure (ALF) | Rare | Efferocytosis of Inflammatory Dying Cells | |||
Acute on Chronic | Rare | Efferocytosis of Inflammatory Dying Cells /Phagocytosis of Pathological Fibroblast | |||||
Pulmonary Arterial | Rare | Phagocytosis of Pathological Fibroblast | |||||
Idiopathic Pulmonary | Rare | Phagocytosis of Pathological Fibroblast | |||||
Liver Fibrosis | Refractory | Phagocytosis of Pathological Fibroblast | |||||
MSS Colorectal Cancer | Refractory | Phagocytosis of Cancer Cell | |||||
SBI-201 [HIF1α-NV] | Transcription Factor | Undisclosed | Undisclosed | Resolutive Immunity Activation | |||
SBI-301 | mRNA | Undisclosed | Undisclosed | Undisclosed | |||
SBI-302 | siRNA | Undisclosed | Undisclosed | Undisclosed | |||
