Our proprietary NSM scaffold harnesses cellular biogenesis to generate precision-targeted natural nanoparticles (NNPs) that deliver diverse payloads directly to their intended sites

NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

SHIFTBIO NNP Design AI™

Innovative NNP Design for Revolutionary Targeted Delivery

Our proprietary NSM scaffold harnesses cellular biogenesis to generate

precision-targeted natural nanoparticles (NNPs) that deliver diverse payloads directly to their intended sites

NNP Sorting Motif (NSM) Scaffold

NSM-based NNP Generation from Cells

Key Advantages

High design success rate	Multiplex cargo loading	Universal cell applications

Key Advantages

High design

success rate

Multiplex

cargo loading

Universal cell

applications

NNP Design AI™ Platform

NSM operates through protein-protein interactions (PPIs), enabling precise NNP design prediction using in silico molecular modeling

01

NSM structure modeling

02

Predicting NSM-based

NNP generation success rate

through PPI analysis

03

Refining NNP through

MD simulations

NNP Design AI™ Platform

NSM operates through protein-protein interactions (PPIs),

enabling precise NNP design prediction using in silico molecular modeling

01

NSM structure modeling

02

Predicting NSM-based NNP generation success rate through PPI analysis

03

Refining NNP through

MD simulations

Traditional Drug Design Strategy

NNP Design AI™ Platform

4–5 years or more	Period	A few months
High	Cost	Low
Complex experiments, repetitive validation	Process	Simple data analysis and prediction
High	Failure Risk	Low (Risk mitigation)